Answer: You really need to ask your Doctor about thisI live with someone who is prescribed Trazadone and she's usually in bed when taking the meds.because it makes her sleepyThere are no safe combinations if you want to have God's own certainty, and this would not be a good combination for a do-it-yourself project, but what you're doing under a physician's supervision is certainly reasonable. Have you called the office to tell them the larger dose was a bit much? Just a reminder.