Answer: Depending upon a bunch of variables including age, body mass, the actual drug ingested, and the total quantity of alcohol consumed -- yes.In particular, since barbiturates (a type of sleeping pill) and alcohol are both central nervous system depressants they will have an additive effect. An overdose of pills combined with a quantity of alcohol can easily lead to coma and then death.Yeah, this will put you into a coma, and then death. I certainly hope you arent seriously entertaining the thought of actually doing this. If you are, SEEK HELP! I've taken ONE pill (halcyon)with ONE SHOT of whiskey (well, vodka), and it just made me sleep well. But a WHOLE bottle of pills? That alone will kill you. NOT SMART!!!!!!!! (unless you DO want to die.)I mean think about it, sleeping pills are meant to aide in sleep if you take ONE. Its pretty obvious what a whole bottle will do.